Pharmacokinetic Drug Interaction Studies with Enzalutamide
نویسندگان
چکیده
منابع مشابه
Pharmacokinetic Drug Interaction Studies with Enzalutamide
BACKGROUND AND OBJECTIVES Two phase I drug interaction studies were performed with oral enzalutamide, which is approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). METHODS A parallel-treatment design (n = 41) was used to evaluate the effects of a strong cytochrome P450 (CYP) 2C8 inhibitor (oral gemfibrozil 600 mg twice daily) or strong CYP3A4 inhibitor (oral ...
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BACKGROUND AND OBJECTIVES Oral enzalutamide (160 mg once daily) is approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). This article describes the pharmacokinetics of enzalutamide and its active metabolite N-desmethyl enzalutamide. METHODS Results are reported from five clinical studies. RESULTS In a dose-escalation study (n = 140), enzalutamide half-life w...
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ژورنال
عنوان ژورنال: Clinical Pharmacokinetics
سال: 2015
ISSN: 0312-5963,1179-1926
DOI: 10.1007/s40262-015-0283-1